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Article

Association of promoter polymorphisms in MMP2 and TIMP2 with prostate cancer susceptibility in North India.

Archives of medical research - 1 Feb 2012

Srivastava Priyanka, Lone Tasleem A, Kapoor Rakesh, Mittal Rama Devi

Abstract excerpt

BACKGROUND AND AIMS: The importance of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in tumor progression is well documented. MMP2/TIMP2 system has a significant impact on the development and progression of cancer and genetic polymorphisms in the promoters of MMP2 (-1306C/T, 735C/T) and TIMP2 (-418G/A, -303C/T) are correlated with decreased enzyme activity. We sought to determine whether...

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Identifiers

PMID: 22374248
DOI: 10.1016/j.arcmed.2012.02.006

Genes

MMP2
TIMP2

Provenance

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