Article
Genetic polymorphisms of matrix metalloproteinases: susceptibility and prognostic implications for prostate cancer.
The Journal of urology - 1 May 2009
Dos Reis Sabrina Thalita, Pontes José, Villanova Fabiola Elizabeth, Borra Priscila Maria de Andrade, Antunes Alberto Azoubel, Dall'oglio Marcos Francisco, Srougi Miguel, Leite Katia Ramos Moreira
Abstract excerpt
PURPOSE: Prostate cancer is the most common tumor in males in Brazil. Single nucleotide polymorphisms have been demonstrated to exist in the promoter regions of matrix metalloproteinase genes and they are associated with the development and progression of some cancers. We investigated the correlation between MMP1, 2, 7 and 9 polymorphisms with susceptibility to prostate cancer, and classic prognostic parameters...
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