Article
TCRBV CDR3 diversity of CD4+ and CD8+ T-lymphocytes in HIV-infected individuals.
Human immunology - 1 Jan 2002
Raaphorst Frank M, Schelonka Robert L, Rusnak Janice, Infante Anthony J, Teale Judy M
Abstract excerpt
TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with CD4 counts >500, CD4+ TCRBV CDR3 fingerprinting profiles contained subtle variations with...
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