Article
Effect of PON1 Q192R genetic polymorphism on clopidogrel efficacy and cardiovascular events in the Clopidogrel in the Unstable Angina to Prevent Recurrent Events trial and the Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events.
Circulation. Cardiovascular genetics - 1 Apr 2012
Paré Guillaume, Ross Stephanie, Mehta Shamir R, Yusuf Salim, Anand Sonia S, Connolly Stuart J, Fox Keith A A, Eikelboom John W
Abstract excerpt
BACKGROUND: A recent report suggested that carriers of the Q allele of the PON1 Q192R polymorphism had decreased biotransformation of clopidogrel into its active metabolite and decreased efficacy of clopidogrel in preventing cardiovascular events. Furthermore, PON1 has been reported to have a central role in the antioxidant function of high-density lipoprotein, and the Q192R polymorphism has been previously...
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