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CYP2C19 and effect of clopidogrel for secondary prevention of major ischemic events: systematic review and meta-analysis

2023-08-20

Abstract excerpt

<h4>Background</h4> Carriers of the CYP2C19 Loss of Function (LoF) allele may experience decreased efficacy of clopidogrel in secondary prevention after cardiovascular events. Randomized clinical trials of clopidogrel in patients with known CYP2C19 carrier status provided inconsistent results. Our aim was to pool the evidence on the effect of clopidogrel on outcome, according to CYP2C19 LoF status, in a meta-analy...

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Literature Corpus work
417012ab-fcd8-5736-93ae-06771ec24d5f
DOI
10.1101/2023.08.17.23292850
Open publication

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