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Article

UDP-glucuronosyltransferase 1A4 (UGT1A4) polymorphisms in a Jordanian population.

Molecular biology reports - 1 Jul 2012

Hakooz Nancy, Alzubiedi Sameh, Yousef Al-Motassem, Arafat Tawfiq, Dajani Rana, Ababneh Nidaa, Ismail Said

Abstract excerpt

Glucuronidation is one of the most important phase II metabolic pathways. It is catalyzed by a family of UDP-glucuronosyltransferase enzymes (UGTs). One of the subfamilies is UGT1A. Allele frequencies in UGT1A4 differ among ethnic groups. The aim of this study was to determine the allelic frequency of two most common defective alleles: UGT1A4*2 and UGT1A4*3 in a Jordanian population. A total of 216 healthy...

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PMID: 22367373
DOI: 10.1007/s11033-012-1615-y

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