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Article

Costimulatory pathways in transplantation

8 Jun 2011

Abstract excerpt

Secondary, so-called costimulatory, signals are critically required for the process of T cell activation. Since landmark studies defined that T cells receiving a T cell receptor signal without a costimulatory signal, are tolerized in vitro, the investigation of T cell costimulation has attracted intense interest. Early studies demonstrated that interrupting T cell costimulation allows attenuation of the...

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Identifiers

PMID: 21616680
DOI: 10.1016/j.smim.2011.04.002

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