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Article

Phenotypic and functional analysis of T-cell recovery after anti-CD3 immunotoxin treatment for tolerance induction in rhesus macaques.

Human immunology - 1 May 2001

Hubbard W J, Moore J K, Contreras J L, Smyth C A, Chen Z W, Lobashevsky A L, Nagata K, Neville D M, Thomas J M

Abstract excerpt

T-cell reduction utilizing specific antibody has been widely used in human transplantation, and is a cornerstone of several tolerance induction strategies in nonhuman primates. We have established a population of long-term tolerant rhesus macaques induced with an anti-CD3epsilon immunotoxin (IT). This treatment effects transient, specific and profound ablation of T cells in blood and lymphoid tissues. In most...

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PMID: 11334671
DOI: 10.1016/s0198-8859(01)00235-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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