Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hydroxyurea induces de novo copy number variants in human cells.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2011

Arlt Martin F, Ozdemir Alev Cagla, Birkeland Shanda R, Wilson Thomas E, Glover Thomas W

Abstract excerpt

Copy number variants (CNVs) are widely distributed throughout the human genome, where they contribute to genetic variation and phenotypic diversity. Spontaneous CNVs are also a major cause of genetic and developmental disorders and arise frequently in cancer cells. As with all mutation classes, genetic and environmental factors almost certainly increase the risk for new and deleterious CNVs. However, despite the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aphidicolin
Share to Chromosomes, Human, Pair 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks

Share to DNA Copy Number Variations

Share to DNA Replication

Share to Enzyme Inhibitors

Share to Hydroxyurea

Share to Ribonucleotide Reductases

Source

Open in PubMed Open full text

Identifiers

PMID: 21987784
DOI: 10.1073/pnas.1109272108
PMCID: PMC3198378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hydroxyurea induces de novo copy number variants in human cells.PMID 21987784Read ↗

Replication stress and mechanisms of CNV formation.Semantic proximity Read ↗

Copy number variants are produced in response to low-dose ionizing radiation in cultured cells.Semantic proximity Read ↗

Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants.Semantic proximity Read ↗

Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing.Semantic proximity Read ↗

The multiple de novo copy number variant (MdnCNV) phenomenon presents with peri-zygotic DNA mutational signatures and multilocus pathogenic variation.Semantic proximity Read ↗

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity.Semantic proximity Read ↗

Absence of heterozygosity due to template switching during replicative rearrangements.Semantic proximity Read ↗

Evaluating the genomic and sequence integrity of human ES cell lines; comparison to normal genomes.Semantic proximity Read ↗

Redefining copy number variation and single-nucleotide polymorphism counting via novel concepts based on recent PCR enhancements.Semantic proximity Read ↗

Elevated variant density around SV breakpoints in germline lineage lends support to error-prone replication hypothesis.Semantic proximity Read ↗

Copy number variant analysis of human embryonic stem cells.Semantic proximity Read ↗

An Organismal CNV Mutator Phenotype Restricted to Early Human Development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.