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Article

Copy number variants are produced in response to low-dose ionizing radiation in cultured cells.

Environmental and molecular mutagenesis - 1 Mar 2014

Arlt Martin F, Rajendran Sountharia, Birkeland Shanda R, Wilson Thomas E, Glover Thomas W

Abstract excerpt

Despite their importance to human genetic variation and disease, little is known about the molecular mechanisms and environmental risk factors that impact copy number variant (CNV) formation. While it is clear that replication stress can lead to de novo CNVs, for example, following treatment of cultured mammalian cells with aphidicolin (APH) and hydroxyurea (HU), the effect of different types of mutagens on CNV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24327335
DOI: 10.1002/em.21840
PMCID: PMC4086151

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