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Article

Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants.

American journal of human genetics - 1 Mar 2009

Arlt Martin F, Mulle Jennifer G, Schaibley Valerie M, Ragland Ryan L, Durkin Sandra G, Warren Stephen T, Glover Thomas W

Abstract excerpt

Copy number variants (CNVs) are an important component of genomic variation in humans and other mammals. Similar de novo deletions and duplications, or copy number changes (CNCs), are now known to be a major cause of genetic and developmental disorders and to arise somatically in many cancers. A major mechanism leading to both CNVs and disease-associated CNCs is meiotic unequal crossing over, or nonallelic...

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Identifiers

PMID: 19232554
DOI: 10.1016/j.ajhg.2009.01.024
PMCID: PMC2667984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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