Article
An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria.
PloS one - 1 Jan 2012
Bongfen Silayuv E, Rodrigue-Gervais Ian-Gael, Berghout Joanne, Torre Sabrina, Cingolani Pablo, Wiltshire Sean A, Leiva-Torres Gabriel A, Letourneau Louis, Sladek Robert, Blanchette Mathieu, Lathrop Mark, Behr Marcel A, Gruenheid Samantha, Vidal Silvia M, Saleh Maya, Gros Philippe
Abstract excerpt
Cerebral malaria (CM) is a lethal neurological complication of malaria. We implemented a genome-wide screen in mutagenized mice to identify host proteins involved in CM pathogenesis and whose inhibition may be of therapeutic value. One pedigree (P48) segregated a resistance trait whose CM-protective effect was fully penetrant, mapped to chromosome 8, and identified by genome sequencing as homozygosity for a...
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