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Article

AR-Q640X, a model to study the effects of constitutively active C-terminally truncated AR variants in prostate cancer cells.

World journal of urology - 1 Jun 2012

Streicher Wolfgang, Zengerling Friedemann, Laschak Martin, Weidemann Wolfgang, Höpfner Michael, Schrader Andres J, Jentzmik Florian, Schrader Mark, Cronauer Marcus V

Abstract excerpt

PURPOSE: A recently identified mechanism allowing prostate cancer (PCa) cells to grow in the absence of androgens is the expression of constitutively active, C-terminally truncated androgen receptor (AR) variants lacking vast parts of the ligand-binding domain. These AR variants termed ARΔLBD are either products of alternative splicing, point mutations leading to premature stop codons or proteolytic cleavage of...

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PMID: 22362413
DOI: 10.1007/s00345-012-0842-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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