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Article

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

19 Jul 2010

Abstract excerpt

Progression of prostate cancer following castration is associated with increased androgen receptor (AR) expression and signaling despite AR blockade. Recent studies suggest that these activities are due to the generation of constitutively active AR splice variants, but the mechanisms by which these splice variants could mediate such effects are not fully understood. Here we have identified what we believe to be a...

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Share to Estrogen and related hormone effects
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PMID: 20644256
DOI: 10.1172/jci41824

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