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Article

C-terminally truncated constitutively active androgen receptor variants and their biologic and clinical significance in castration-resistant prostate cancer.

The Journal of steroid biochemistry and molecular biology - 1 Feb 2017

Azoitei Anca, Merseburger Axel S, Godau Beate, Hoda M Raschid, Schmid Evi, Cronauer Marcus V

Abstract excerpt

A mechanism allowing castration resistant prostate cancer cells to escape the effects of conventional anti-hormonal treatments is the synthesis of constitutively active, C-terminally truncated androgen receptor (AR)-variants. Lacking the entire or vast parts of the ligand binding domain, the intended target of traditional endocrine therapies, these AR-variants (termed ARΔLBD) are insensitive to all traditional...

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PMID: 27345700
DOI: 10.1016/j.jsbmb.2016.06.008

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