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Article

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

7 Sept 2010

Abstract excerpt

Androgen receptor (AR) splice variants lacking the ligand binding domain (ARVs), originally isolated from prostate cancer cell lines derived from a single patient, are detected in normal and malignant human prostate tissue, with the highest levels observed in late stage, castration-resistant prostate cancer. The most studied variant (called AR-V7 or AR3) activates AR reporter genes in the absence of ligand and...

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Share to Estrogen and related hormone effects
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PMID: 20823238
DOI: 10.1073/pnas.1012443107

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