Article
Components of the type six secretion system are substrates of Francisella tularensis Schu S4 DsbA-like FipB protein.
Virulence - 16 Nov 2016
Qin Aiping, Zhang Yan, Clark Melinda E, Moore Emily A, Rabideau Meaghan M, Moreau G Brett, Mann Barbara J
Abstract excerpt
FipB, an essential virulence factor in the highly virulent Schu S4 strain of F. tularensis subsp. tularensis, shares sequence similarity with Disulfide Bond formation (Dsb) proteins, which can have oxidoreductase, isomerase, or chaperone activity. To further explore FipB's role in virulence potential substrates were identified by co-purification and 2D gel electrophoresis, followed by protein sequencing using...
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