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Article

Association of K832R and R952K SNPs of Wilson's disease gene with Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Bucossi Serena, Polimanti Renato, Mariani Stefania, Ventriglia Mariacarla, Bonvicini Cristian, Migliore Simone, Manfellotto Dario, Salustri Carlo, Vernieri Fabrizio, Rossini Paolo M, Squitti Rosanna

Abstract excerpt

Copper homeostasis appears abnormal in Alzheimer's disease (AD) patients. The aim of this study was to assess whether loci of susceptibility for AD lie in the Wilson's disease (WD) ATP7B gene. We studied single nucleotide polymorphisms (SNPs) K832R (c.2495 A>G, rs1061472) and R952K (c. 2855 G>A, rs732774) of the WD gene in 251 AD patients and 201 healthy controls. We also evaluated their relation with...

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PMID: 22356903
DOI: 10.3233/JAD-2012-111997

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