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Copper Imbalance in Alzheimer's Disease: Meta-Analysis of Serum, Plasma, and Brain Specimens, and Replication Study Evaluating ATP7B Gene Variants.

Biomolecules - 29 Jun 2021

Squitti Rosanna, Ventriglia Mariacarla, Simonelli Ilaria, Bonvicini Cristian, Costa Alfredo, Perini Giulia, Binetti Giuliano, Benussi Luisa, Ghidoni Roberta, Koch Giacomo, Borroni Barbara, Albanese Alberto, Sensi Stefano L, Rongioletti Mauro

Abstract excerpt

Evidence indicates that patients with Alzheimer's dementia (AD) show signs of copper (Cu) dyshomeostasis. This study aimed at evaluating the potential of Cu dysregulation as an AD susceptibility factor. We performed a meta-analysis of 56 studies investigating Cu biomarkers in brain specimens (pooled total of 182 AD and 166 healthy controls, HC) and in serum/plasma (pooled total of 2929 AD and 3547 HC). We also...

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Identifiers

PMID: 34209820
DOI: 10.3390/biom11070960
PMCID: PMC8301962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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