Predictive value of ERCC2, ABCC2 and MMP2 of response and long-term survival in locally advanced head and neck cancer patients treated with chemoradiotherapy.

doi:10.1007/s00280-021-04330-1

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Predictive value of ERCC2, ABCC2 and MMP2 of response and long-term survival in locally advanced head and neck cancer patients treated with chemoradiotherapy.

Cancer chemotherapy and pharmacology - 1 Nov 2021

Duran Goretti, Cruz Raquel, Aguín Santiago, Barros Francisco, Giráldez José María, Bernárdez Beatriz, Zarra Irene, López-López Rafael, Carracedo Ángel, Lamas María Jesús

Abstract excerpt

PURPOSE: Genetic variants in genes involved in the distribution, metabolism, accumulation or repair of lesions are likely to influence the response of drugs used in the treatment of Head and Neck Cancer (HNC). We examine the effect of 36 SNPs on clinical outcomes in patients with locally advanced HNC who were receiving platinum-based chemoradiotherapy (CRT). METHODS: These SNPs were genotyped in 110 patients...

Topics

Adult
Aged
Aged, 80 and over
Chemoradiotherapy
Female
Gene Frequency
Haplotypes
Head and Neck Neoplasms
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Matrix Metalloproteinase 2

Middle Aged

Multidrug Resistance-Associated Protein 2

Pharmacogenomic Variants

Polymorphism, Single Nucleotide

Treatment Outcome

Xeroderma Pigmentosum Group D Protein

Source

Open in PubMed

Identifiers

PMID: 34309735
DOI: 10.1007/s00280-021-04330-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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