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Article

Mutational analysis of the analgesic peptide DrTx(1-42) revealing a functional role of the amino-terminal turn.

PloS one - 1 Jan 2012

Li Ping, Zhu Shunyi

Abstract excerpt

BACKGROUND: DrTx(1-42) (a carboxyl-terminally truncated version of drosotoxin) is a potent and selective blocker of tetrodotoxin-resistant (TTX-R) Na(+) channels in rat dorsal root ganglion neurons with analgesic activity. This purpose is to identify key amino acids which are responsible for both...

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Identifiers

PMID: 22355398
DOI: 10.1371/journal.pone.0031830
PMCID: PMC3280213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22355398-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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