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Article

Virologic failures on initial boosted-PI regimen infrequently possess low-level variants with major PI resistance mutations by ultra-deep sequencing.

PloS one - 1 Jan 2012

Lataillade Max, Chiarella Jennifer, Yang Rong, DeGrosky Michelle, Uy Jonathan, Seekins Daniel, Simen Birgitte, St John Elizabeth, Moreno Elizabeth, Kozal Michael

Abstract excerpt

BACKGROUND: It is unknown whether HIV-positive patients experiencing virologic failure (VF) on boosted-PI (PI/r) regimens without drug resistant mutations (DRM) by standard genotyping harbor low-level PI resistant variants. CASTLE compared the efficacy of atazanavir/ritonavir (ATV/r) with lopinavir/ritonavir (LPV/r), each in combination with TVD in ARV-naïve subjects. OBJECTIVE: To determine if VF on an initial...

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Identifiers

PMID: 22355307
DOI: 10.1371/journal.pone.0030118
PMCID: PMC3280244

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