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Article

Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naïve subjects in the CASTLE study.

PloS one - 3 Jun 2010

Lataillade Max, Chiarella Jennifer, Yang Rong, Schnittman Steven, Wirtz Victoria, Uy Jonathan, Seekins Daniel, Krystal Mark, Mancini Marco, McGrath Donnie, Simen Birgitte, Egholm Michael, Kozal Michael

Abstract excerpt

BACKGROUND: CASTLE compared the efficacy of atazanavir/ritonavir with lopinavir/ritonavir, each in combination with tenofovir-emtricitabine in ARV-naïve subjects from 5 continents. OBJECTIVES: Determine the baseline rate and clinical significance of TDR mutations using ultra-deep sequencing (UDS)...

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Identifiers

PMID: 20532178
DOI: 10.1371/journal.pone.0010952
PMCID: PMC2880604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20532178-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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