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Article

Microenvironmental control of stem cell fate in intestinal homeostasis and disease.

The Journal of pathology - 1 Oct 2015

Biswas Sujata, Davis Hayley, Irshad Shazia, Sandberg Tessa, Worthley Daniel, Leedham Simon

Abstract excerpt

The conventional model of intestinal epithelial architecture describes a unidirectional tissue organizational hierarchy with stem cells situated at the crypt base and daughter cells proliferating and terminally differentiating as they progress along the vertical (crypt-luminal) axis. In this model, the fate of a cell that has left the niche is determined and its lifespan limited. Evidence is accumulating to...

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Identifiers

PMID: 25974319
DOI: 10.1002/path.4563
PMCID: PMC4744721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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