Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow.

doi:10.1084/jem.20110994

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Article

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow.

The Journal of experimental medicine - 12 Mar 2012

Mansour Anna, Abou-Ezzi Grazia, Sitnicka Ewa, Jacobsen Sten Eirik W, Wakkach Abdelilah, Blin-Wakkach Claudine

Abstract excerpt

Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the HSC niche formation. The absence of OCL activity...

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Identifiers

PMID: 22351931
DOI: 10.1084/jem.20110994
PMCID: PMC3302238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.