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Article

Committed osteoclast precursors colonize the bone and improve the phenotype of a mouse model of autosomal recessive osteopetrosis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2010

Cappariello Alfredo, Berardi Anna Concetta, Peruzzi Barbara, Del Fattore Andrea, Ugazio Alberto, Bottazzo Gian Franco, Teti Anna

Abstract excerpt

Osteopetrosis is a genetic disease characterized by defective osteoclasts. Autosomal recessive osteopetrosis is fatal within the first years of life. Hematopoietic stem cell transplantation (HSCT) cures fewer than 50% of cases but often leaves severe neurologic damages and other dysfunctions. Osteoclast appearance after HSCT is a slow process, during which disease progression continues. We hypothesize that a...

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PMID: 20091929
DOI: 10.1359/jbmr.090715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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