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Article

Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization.

Neuro-degenerative diseases - 1 Jan 2012

Ben Khalifa N, Tyteca D, Courtoy P J, Renauld J C, Constantinescu S N, Octave J N, Kienlen-Campard P

Abstract excerpt

BACKGROUND: The two major isoforms of the human amyloid precursor protein (APP) are APP695 and APP751. They differ by the insertion of a Kunitz-type protease inhibitor (KPI) sequence in the extracellular domain of APP751. APP-KPI isoforms are increased in Alzheimer's disease brains, and they could be associated with disease progression. Recent studies have shown that APP processing to Aβ is regulated by...

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Source

Identifiers

PMID: 22343802
DOI: 10.1159/000335225

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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