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Article

Assessment of closely related Mycobacterium tuberculosis variants with different transmission success and in vitro infection dynamics.

Scientific reports - 26 May 2021

Abascal Estefanía, Genestet Charlotte, Valera Ana, Herranz Marta, Martinez-Lirola Miguel, Muñoz Patricia, Dumitrescu Oana, García de Viedma Darío

Abstract excerpt

Whole genome sequencing (WGS) is able to differentiate closely related Mycobacterium tuberculosis variants within the same transmission cluster. Our aim was to evaluate if this higher discriminatory power may help identify and characterize more actively transmitted variants and understand the factors behind their success. We selected a robust MIRU-VNTR-defined cluster from Almería, Spain (22 cases throughout...

Topics

Cell Line
Humans
Macrophages
Models, Theoretical
Mycobacterium tuberculosis
Polymorphism, Single Nucleotide
Tuberculosis
Whole Genome Sequencing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34040136
DOI: 10.1038/s41598-021-90568-x
PMCID: PMC8155013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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