Article
The tempo and mode of molecular evolution of Mycobacterium tuberculosis at patient-to-patient scale.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2010
Schürch Anita C, Kremer Kristin, Kiers Albert, Daviena Olaf, Boeree Martin J, Siezen Roland J, Smith Noel H, van Soolingen Dick
Abstract excerpt
A total of six polymorphisms were identified by comparing the genomes of the first and the last isolate of a well-characterized transmission chain of Mycobacterium tuberculosis involving five patients over a 12 and a half year period. The six polymorphisms consisted of four single nucleotide changes (SNPs), a tandem repeat polymorphism (TRP) and a previously identified IS6110 transposition event. These...
Topics
- DNA Transposable Elements
- DNA, Bacterial
- Evolution, Molecular
- Genome, Bacterial
- Humans
- Molecular Epidemiology
- Mutation
- Mycobacterium tuberculosis
- Polymorphism, Genetic
- Sequence Analysis, DNA