Article
A genetic association study of the CLEC12A gene in rheumatoid arthritis.
Joint bone spine - 1 Oct 2012
Michou Laëtitia, Cornélis François, Levesque Jean-Michel, Bombardieri Stefano, Balsa Alejandro, Westhovens René, Barrera Pilar, Alves Helena, van de Putte Leo, Migliorini Paola, Bardin Thomas, Petit-Teixeira Elisabeth, Fernandes Maria J G
Abstract excerpt
OBJECTIVE: The CLEC12A gene codes for an immune inhibitory receptor that maps to 12p13.2. Since an increase in CLEC12A mRNA correlates with rheumatoid factor values greater than 40 IU/ml in rheumatoid fibroblast-like synovial cells, this study assessed the potential of an association between CLEC12A and rheumatoid arthritis (RA) using a phenotype-based approach. METHODS: A discovery cohort of Western European...
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