Article
The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development.
Molecular biology of the cell - 1 Jun 2012
Ballim Reyna Deeya, Mendelsohn Cathy, Papaioannou Virginia E, Prince Sharon
Abstract excerpt
TBX3, a member of the T-box transcription factor gene family, is a transcriptional repressor that is required for the development of the heart, limbs, and mammary glands. Mutations in TBX3 that result in reduced functional protein lead to ulnar-mammary syndrome, a developmental disorder character...
Topics
- Abnormalities, Multiple
- Animals
- Blotting, Western
- Breast Diseases
- Cell Line, Tumor
- Embryo, Mammalian
- Extremities
- Female
- Gene Expression Regulation, Developmental
- HEK293 Cells
- Humans
- In Situ Hybridization
- Luciferases
- Male
- Mice