Article
Female reproductive factors, gene polymorphisms in the estrogen metabolism pathway, and risk of lung cancer in Chinese women.
American journal of epidemiology - 15 Mar 2012
Lim Wei-Yen, Chen Ying, Chuah Khoon Leong, Eng Philip, Leong Swan Swan, Lim Elaine, Lim Tow Keang, Ng Alan, Poh Wee Teng, Tee Augustine, Teh Ming, Salim Agus, Seow Adeline
Abstract excerpt
The authors examined relations between reproductive factors and 5 estrogen pathway gene polymorphisms (CYP17 rs743572, CYP19A1 rs10046, ERβ rs1256049, ERβ rs4986938, and COMT rs4680) among 702 Singapore Chinese female lung cancer cases and 1,578 hospital controls, of whom 433 cases (61.7%) and 1,375 controls (87.1%) were never smokers. Parity (per child, odds ratio (OR) = 0.92, 95% confidence interval (CI): 0.87,...