Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer.

doi:10.1155/2016/2769804

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Article

Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer.

Oxidative medicine and cellular longevity - 1 Jan 2016

Matos Andreia, Castelão Cindy, Pereira da Silva Alda, Alho Irina, Bicho Manuel, Medeiros Rui, Bicho Maria Clara

Abstract excerpt

There is a clear association between the excessive and cumulative exposure to estrogens and the development of cancer in hormone-sensitive tissues, such as the cervix. We studied the association of CYP1A1 M1 (rs4646903) and COMT (rs4680) polymorphisms in 130 cervical cancer cases (c-cancer) and 179 controls. The CYP1A1 TT genotype was associated with a lower risk for c-cancer (OR = 0.39, p = 0.002). The allele C...

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Identifiers

PMID: 26798414
DOI: 10.1155/2016/2769804
PMCID: PMC4698955

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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