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Article

Obovatol improves cognitive functions in animal models for Alzheimer's disease.

Journal of neurochemistry - 1 Mar 2012

Choi Dong-Young, Lee Jae Woong, Peng Jin, Lee Young Jung, Han Jin-Yi, Lee Yeon Hee, Choi Im Seop, Han Sang Bae, Jung Jae Kyung, Lee Woong Soo, Lee Seung-Ho, Kwon Byoung-Mog, Oh Ki-Wan, Hong Jin Tae

Abstract excerpt

Etiology of Alzheimer's disease (AD) is obscure, but neuroinflammation and accumulation of β-amyloid (Aβ) are implicated in pathogenesis of AD. We have shown anti-inflammatory and neurotrophic properties of obovatol, a biphenolic compound isolated from Magnolia obovata. In this study, we examined the effect of obovatol on cognitive deficits in two separate AD models: (i) mice that received intracerebroventricular...

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PMID: 22212065
DOI: 10.1111/j.1471-4159.2011.07642.x

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BACE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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