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NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer’s Disease

13 Nov 2019

Abstract excerpt

Alzheimer's Disease (AD) is a neurodegenerative disease and the main cause of dementia. Its major symptom is memory loss, which is a result of neuronal cell death, which is accompanied by neuroinflammation. Some studies indicate the overactivation of the phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (Akt)/ mechanistic target of rapamycin (mTOR) pathway in this disease, being, thus, a potential target for...

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PMID: 31798451
DOI: 10.3389/fphar.2019.01345

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