Article
Screening of GLE1 mutations in Chinese amyotrophic lateral sclerosis patients.
Neurobiology of aging - 1 Jun 2018
Zhang Kang, Liu Qing, Shen Dongchao, Tai Hongfei, Fu Hanhui, Liu Shuangwu, Chen Jinyi, Li Xiaoguang, Liu Mingsheng, Zhang Xue, Cui Liying
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a lethal neurological disease primarily involving the spinal cord, brainstem, and corticospinal tract. Recently, mutations in the GLE1 gene were reported in Caucasian ALS patients. To inquire whether Chinese ALS patients carried causal mutations in the gene, we screened all 16 coding exons of GLE1 with Sanger sequencing in a Han Chinese cohort of 250 ALS cases. No...
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