Article
Extending and evaluating a warfarin dosing algorithm that includes CYP4F2 and pooled rare variants of CYP2C9.
Pharmacogenetics and genomics - 1 Jul 2010
Sagreiya Hersh, Sagrieya Hersh, Berube Caroline, Wen Alice, Ramakrishnan Ramesh, Mir Alain, Hamilton Amy, Altman Russ B
Abstract excerpt
OBJECTIVE: Warfarin dosing remains challenging because of its narrow therapeutic window and large variability in dose response. We sought to analyze new factors involved in its dosing and to evaluate eight dosing algorithms, including two developed by the International Warfarin Pharmacogenetics Consortium (IWPC). METHODS: we enrolled 108 patients on chronic warfarin therapy and obtained complete clinical and...
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