Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status.

Human immunology - 1 Apr 2012

Weiner Lachmi Karin, Lin Ling, Kornum Birgitte Rahbek, Rico Tom, Lo Betty, Aran Adi, Mignot Emmanuel

Abstract excerpt

The association of narcolepsy-cataplexy, a sleep disorder caused by the loss of hypocretin/orexin neurons in the hypothalamus, with DQA1*01:02-DQB1*06:02 is one of the tightest known single-allele human leukocyte antigen (HLA) associations. In this study, we explored genome-wide expression in peripheral white blood cells of 50 narcolepsy versus 47 controls (half of whom were DQB1*06:02 positive) and observed the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to B-Lymphocytes
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Gene Expression

Share to Gene Expression Profiling

Share to HLA-DQ beta-Chains

Share to Narcolepsy

Source

Open in PubMed Open full text

Identifiers

PMID: 22326585
DOI: 10.1016/j.humimm.2012.01.004
PMCID: PMC3501142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status.PMID 22326585Read ↗

HLA dosage effect in narcolepsy with cataplexy.Semantic proximity Read ↗

Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.Semantic proximity Read ↗

Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.Semantic proximity Read ↗

HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency.Semantic proximity Read ↗

HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity.Semantic proximity Read ↗

DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans.Semantic proximity Read ↗

New susceptibility variants to narcolepsy identified in HLA class II region.Semantic proximity Read ↗

HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy.Semantic proximity Read ↗

Does narcolepsy symptom severity vary according to HLA-DQB1*0602 allele status?Semantic proximity Read ↗

Association between human leukocyte antigen class II-DR-DQ and narcolepsy: a case control study.Semantic proximity Read ↗

MX2 gene expression tends to be downregulated in subjects with HLA-DQB1*0602.Semantic proximity Read ↗

A series of 7 cases of patients with narcolepsy with hypocretin deficiency without the HLA DQB1*06:02 allele.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.