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Article

The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1.

Human genetics - 1 Nov 1990

Dudley C R, Giuffra L A, Tippett P, Kidd K K, Reeders S T

Abstract excerpt

The Na+/H+ antiporter is a ubiquitous membrane-associated protein that plays an important role in the regulation of intracellular pH. APNH, a gene encoding the antiporter, has been cloned and mapped to the short arm of chromosome 1 by in situ hybridization. Using the polymerase chain reaction, we have amplified a 376 base pair fragment corresponding to the 5' end of APNH. We have detected a polymorphism within...

Topics

Alleles
Carrier Proteins
Chromosome Mapping
Chromosomes, Human, Pair 1
DNA Probes
Female
Genetic Linkage
Genetic Markers
Humans
Male
Pedigree
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Sodium-Hydrogen Exchangers

Source

Identifiers

PMID: 1979310
DOI: 10.1007/BF00205179

Genes

ALPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1979310-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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