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Article

Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.

PloS one - 1 Jan 2012

White Mark A, Li Sheng, Tsalkova Tamara, Mei Fang C, Liu Tong, Woods Virgil L, Cheng Xiaodong

Abstract excerpt

Exchange proteins directly activated by cAMP (EPACs) are important allosteric regulators of cAMP-mediated signal transduction pathways. To understand the molecular mechanism of EPAC activation, we have combined site-directed mutagenesis, X-ray crystallography, and peptide amide hydrogen/deuterium exchange mass spectrometry (DXMS) to probe the structural and conformational dynamics of EPAC2-F435G, a constitutively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23189173
DOI: 10.1371/journal.pone.0049932
PMCID: PMC3506601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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