Article
Association between systemic lupus erythematosus and insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene.
Clinical and experimental rheumatology - 1 Jan 2000
Pullmann R, Lukác J, Skerenová M, Rovensky J, Hybenová J, Melus V, Celec S, Pullmann R, Hyrdel R
Abstract excerpt
OBJECTIVE: ACE takes part in the renin-angiotensin and kallikrein-kininogen systems by creating angiotensin-II and inactivating bradykinin. ACE gene insertion/deletion polymorphism is associated with the level of circulating enzymes--subjects with the DD genotype have higher levels of circulating ACE than subjects with the II genotype and show an increased tendency towards impaired vascular function and...
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