Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence heterogeneity in NS5A of hepatitis C virus genotypes 2a and 2b and clinical outcome of pegylated-interferon/ribavirin therapy.

PloS one - 1 Jan 2012

El-Shamy Ahmed, Shoji Ikuo, Kim Soo-Ryang, Ide Yoshihiro, Imoto Susumu, Deng Lin, Yoon Seitetsu, Fujisawa Takashi, Tani Satoshi, Yano Yoshihiko, Seo Yasushi, Azuma Takeshi, Hotta Hak

Abstract excerpt

UNLABELLED: Pegylated-interferon plus ribavirin (PEG-IFN/RBV) therapy is a current standard treatment for chronic hepatitis C. We previously reported that the viral sequence heterogeneity of part of NS5A, referred to as the IFN/RBV resistance-determining region (IRRDR), and a mutation at position 70 of the core protein of hepatitis C virus genotype 1b (HCV-1b) are significantly correlated with the outcome of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Hepacivirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Interferon-alpha

Share to Polyethylene Glycols

Share to Recombinant Proteins

Share to Ribavirin

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22319571
DOI: 10.1371/journal.pone.0030513
PMCID: PMC3271109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence heterogeneity in NS5A of hepatitis C virus genotypes 2a and 2b and clinical outcome of pegylated-interferon/ribavirin therapy.PMID 22319571Read ↗

Sequence heterogeneity of NS5A and core proteins of hepatitis C virus and virological responses to pegylated-interferon/ribavirin combination therapy.Semantic proximity Read ↗

Impact of hepatitis C virus heterogeneity on interferon sensitivity: an overview.Semantic proximity Read ↗

NS5A sequence heterogeneity of hepatitis C virus genotype 4a predicts clinical outcome of pegylated-interferon-ribavirin therapy in Egyptian patients.Semantic proximity Read ↗

Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy.Semantic proximity Read ↗

Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection.Semantic proximity Read ↗

Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy.Semantic proximity Read ↗

Amino acid substitutions in the nonstructural region 5A of hepatitis C virus genotypes 2a and 2b and its relation to viral load and response to interferon.Semantic proximity Read ↗

Mutations in the interferon sensitivity-determining region (nonstructural 5A amino acid 2209-2248) in patients with hepatitis C-1b infection and correlating response to combined therapy of pegylated interferon and ribavirin.Semantic proximity Read ↗

Mutations in different regions of the genome of hepatitis C virus genotype 1b and association with response to interferon therapy.Semantic proximity Read ↗

Mutations in the interferon sensitivity-determining region of hepatitis C virus genotype 2a correlate with response to pegylated-interferon-alpha 2a monotherapy.Semantic proximity Read ↗

Molecular characterization of hepatitis C virus genotype 2a from the entire sequences of four isolates.Semantic proximity Read ↗

Viral decline over 48h and HCV amino acid mutations are related to efficacy of PEG-IFN/ribavirin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.