Article
An ancestral miR-1304 allele present in Neanderthals regulates genes involved in enamel formation and could explain dental differences with modern humans.
Molecular biology and evolution - 1 Jul 2012
Lopez-Valenzuela Maria, Ramírez Oscar, Rosas Antonio, García-Vargas Samuel, de la Rasilla Marco, Lalueza-Fox Carles, Espinosa-Parrilla Yolanda
Abstract excerpt
Genetic changes in regulatory elements are likely to result in phenotypic effects that might explain population-specific as well as species-specific traits. MicroRNAs (miRNAs) are posttranscriptional repressors involved in the control of almost every biological process. These small noncoding RNAs are present in various phylogenetic groups, and a large number of them remain highly conserved at the sequence level....
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