Article
Unique features of PTCH1 mutation spectrum in Chinese sporadic basal cell carcinoma.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Feb 2013
Huang Y S, Bu D F, Li X Y, Ma Z H, Yang Y, Lin Z M, Lu F M, Tu P, Li H
Abstract excerpt
BACKGROUND: Alterations of the PTCH1 gene have been found to contribute to both familial and sporadic basal cell carcinoma (BCC), especially in Caucasian patients. Furthermore, the majority of PTCH1 gene mutations in sporadic BCCs in Caucasian patients carry ultraviolet (UV) signatures, suggesting the key role of UV light in BCC development. However, sporadic BCC in non-Caucasian population has a lower incidence,...
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