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Inherited rare and common variants in PTCH1 and PTCH2 contributing to the predisposition to reproductive cancers.

Gene - 10 Mar 2022

Yang Xin-Hua, Xu Bo-Heng, Zhou Da-Lei, Long Ya-Kang, Liu Qing, Huang Chan, Ye Zu-Lu, He Cai-Yun

Abstract excerpt

PTCH1 and PTCH2 are associated with nevoid basal cell carcinoma syndrome and basal cell carcinoma. We determined the prevalence of their common and rare variants in 877 patients with various reproductive cancers and 296 healthy subjects. Using targeted next-generation sequencing, we found significantly statistical associations of the minor alleles at seven common variants of PTCH1 and PTCH2 with a decreased risk...

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Share to Genetic Predisposition to Disease
Share to Genital Neoplasms, Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Throughput Nucleotide Sequencing

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Source

Identifiers

PMID: 34990798
DOI: 10.1016/j.gene.2021.146157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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