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Article

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease.

Stem cells (Dayton, Ohio) - 1 Apr 2012

Jiang Yan, Cowley Sally A, Siler Ulrich, Melguizo Dario, Tilgner Katarzyna, Browne Cathy, Dewilton Angus, Przyborski Stefan, Saretzki Gabriele, James William S, Seger Reinhard A, Reichenbach Janine, Lako Majlinda, Armstrong Lyle

Abstract excerpt

Chronic granulomatous disease (CGD) is an inherited disorder of phagocytes in which NADPH oxidase is defective in generating reactive oxygen species. In this study, we reprogrammed three normal unrelated patient's fibroblasts (p47(phox) and gp91(phox) ) to pluripotency by lentiviral transduction with defined pluripotency factors. These induced pluripotent stem cells (iPSC) share the morphological features of...

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Identifiers

PMID: 22311747
DOI: 10.1002/stem.1053
PMCID: PMC3593166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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