Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of functional neutrophils from a mouse model of X-linked chronic granulomatous disorder using induced pluripotent stem cells.

PloS one - 3 Mar 2011

Mukherjee Sayandip, Santilli Giorgia, Blundell Michael P, Navarro Susana, Bueren Juan A, Thrasher Adrian J

Abstract excerpt

Murine models of human genetic disorders provide a valuable tool for investigating the scope for application of induced pluripotent stem cells (iPSC). Here we present a proof-of-concept study to demonstrate generation of iPSC from a mouse model of X-linked chronic granulomatous disease (X-CGD), and their successful differentiation into haematopoietic progenitors of the myeloid lineage. We further demonstrate that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Cellular Reprogramming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, X-Linked

Share to Genetic Vectors

Share to Granulomatous Disease, Chronic

Share to Induced Pluripotent Stem Cells

Share to Lentivirus

Share to Neutrophils

Source

Open in PubMed Open full text

Identifiers

PMID: 21408614
DOI: 10.1371/journal.pone.0017565
PMCID: PMC3048300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of functional neutrophils from a mouse model of X-linked chronic granulomatous disorder using induced pluripotent stem cells.PMID 21408614Read ↗

Functional Restoration of gp91phox-Oxidase Activity by BAC Transgenesis and Gene Targeting in X-linked Chronic Granulomatous Disease iPSCs.Semantic proximity Read ↗

Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells.Semantic proximity Read ↗

An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophilsSemantic proximity Read ↗

Third-generation, self-inactivating gp91phoxlentivector corrects the oxidase defect in NOD/SCID mouse–repopulating peripheral blood–mobilized CD34+ cells from patients with X-linked chronic granulomatous diseaseSemantic proximity Read ↗

Long-Term Correction of Phagocyte NADPH Oxidase Activity by Retroviral-Mediated Gene Transfer in Murine X-Linked Chronic Granulomatous DiseaseSemantic proximity Read ↗

Retroviral-Mediated Gene Transfer of gp91phox Into Bone Marrow Cells Rescues Defect in Host Defense Against Aspergillus fumigatus in Murine X-Linked Chronic Granulomatous DiseaseSemantic proximity Read ↗

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease.Semantic proximity Read ↗

Targeted Repair of CYBB in X-CGD iPSCs Requires Retention of Intronic Sequences for Expression and Functional Correction.Semantic proximity Read ↗

Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophilsSemantic proximity Read ↗

Retrovirus-mediated reconstitution of respiratory burst activity in X-linked chronic granulomatous disease cells.Semantic proximity Read ↗

Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic GranulomatosisSemantic proximity Read ↗

Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.