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Article

Functional Restoration of gp91phox-Oxidase Activity by BAC Transgenesis and Gene Targeting in X-linked Chronic Granulomatous Disease iPSCs.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2016

Laugsch Magdalena, Rostovskaya Maria, Velychko Sergiy, Richter Cornelia, Zimmer Ariane, Klink Barbara, Schröck Evelin, Haase Michael, Neumann Katrin, Thieme Sebastian, Roesler Joachim, Brenner Sebastian, Anastassiadis Konstantinos

Abstract excerpt

Chronic granulomatous disease (CGD) is an inherited immunodeficiency, caused by the inability of neutrophils to produce functional NADPH oxidase required for fighting microbial infections. The X-linked form of CGD (X-CGD), which is due to mutations in the CYBB (gp91phox) gene, a component of NADP...

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Source

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Identifiers

PMID: 26316390
DOI: 10.1038/mt.2015.154
PMCID: PMC4886927

Genes

CYBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26316390-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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