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Article

Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells.

The journal of gene medicine - 1 Jan 2000

Saulnier S O, Steinhoff D, Dinauer M C, Zufferey R, Trono D, Seger R A, Hossle J P

Abstract excerpt

BACKGROUND: Chronic granulomatous diseases (CGD) are caused by impaired antimicrobial activity in phagocytes, due to the absence or malfunction of the respiratory burst NADPH oxidase. Two-thirds of the patients have mutations in their X-linked CGD gene encoding gp91phox, the largest subunit of th...

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Source

Identifiers

PMID: 11045425
DOI: 10.1002/1521-2254(200009/10)2:5<317::AID-JGM127>3.0.CO;2-P

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11045425-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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