Article
Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue.
Circulation. Heart failure - 1 Jan 2016
Valero-Muñoz María, Li Shanpeng, Wilson Richard M, Hulsmans Maarten, Aprahamian Tamar, Fuster José J, Nahrendorf Matthias, Scherer Philipp E, Sam Flora
Abstract excerpt
BACKGROUND: Despite the increasing prevalence of heart failure with preserved ejection fraction (HFpEF) in humans, there are no evidence-based therapies for HFpEF. Clinical studies suggest a relationship between obesity-associated dysfunctional adipose tissue (AT) and HFpEF. However, an apparent obesity paradox exists in some HF populations with a higher body mass index. We sought to determine whether HFpEF...
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